DEPAKOTE ER offers convenient therapy initiation and titration for the prophylaxis of migraine headaches. Refer to information below for recommended dosages and other dosing information.

Dosing In Migraine¹

• Recommended starting dose is 500 mg once daily for one week
• Increase dose to 1000 mg once daily at week two and thereafter
• Although DEPAKOTE ER doses other than 1000 mg once daily have not been evaluated in migraine patients, the effective dose range of DEPAKOTE (divalproex sodium delayed-release tablets) in these patients is 500 to 1000 mg per day

Additional Dosing Information¹

• Depakote ER is an extended-release product intended for once-a-day oral administration
• Depakote ER tablets should be swallowed whole and should not be crushed or chewed
• No recommendation regarding the safety of valproate for use at doses above 60 mg/kg/day can be made
• May be taken without regard to meals
• The starting dose in elderly patients should be reduced and dosage should be increased more slowly and with regular monitoring. The ultimate therapeutic dose should be achieved on the basis of both tolerability and clinical response
• As with other valproate products, doses of Depakote ER should be individualized and dose adjustment may be necessary
• If a patient requires smaller dose adjustments than those available with Depakote ER, Depakote (divalproex sodium delayed-release tablets) should be used instead

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