EPILEPSY - DEPAKOTE ER: Smooth Blood Levels
Once-daily DEPAKOTE ER Provides Smoother Blood Levels than DEPAKOTE (divalproex sodium delayed-release tablets)...
Peak-Trough Fluctuations in Blood Levels: Delayed Release vs Extended Release17
Study Design
Multiple-dose, 6-day, 3-way crossover study in healthy subjects (n=14) compared mean plasma VPA levels of Depakote ER 1000 mg qd fasting to Depakote 500 mg q12h fasting. Depakote ER given once-daily produced an average bioavailability of 89% relative to an equal total daily dose of Depakote given BID. The median time to maximum plasma valproate concentrations (Cmax) after Depakote ER administration was 17 hours.
...with Fewer Peaks and Troughs than Depakote Delayed-release Tablets
Peak-Trough Fluctuations in Blood Levels: Delayed Release 1250mg vs Extended Release 1500mg17
Study Design
Multiple-dose, 7-day, 2-way crossover study of unequal daily doses in healthy subjects (n=35) compared mean plasma VPA levels of Depakote ER 1500 mg qd fasting to Depakote 625 mg q12h fasting. The median time to maximum plasma valproate concentrations (Cmax) after Depakote ER administration was 5 hours.
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