BIPOLAR DISORDER - TREATMENT GUIDELINES
To learn about expert-supported guidelines on treating Bipolar Mania with DEPAKOTE (divalproex sodium delayed-release tablets), refer to the following:
- The APA Treatment Guidelines also recommend lithium or an atypical antipsychotic for treating acute mania
- The 2002 APA Guidelines are based on available evidence and clinical consensus. They offer treatment recommendations to help psychiatrists develop plans for the care of adult patients with bipolar disorder
|
- Mania without psychosis‡
- Mania with psychosis§
- Dysphoric mania or true mixed mania
- Classic euphoric mania
- In the Expert Consensus Guidelines, lithium and atypical antipsychotics are also preferred strategies for breakthrough mania
*APA Guidelines recommend valproate
†A written survey was prepared with 60 questions asking about 1369 options for psychopharmacologic and psychotherapeutic interventions. Surveys were sent to 50 national experts, of whom 47 (94%) completed it. Consensus on each option was defined as a nonrandom distribution of scores by chi-square test. A category rank (first-line/preferred, second-line/alternate, third-line/ usually inappropriate) was assigned to each option based on the confidence interval of its mean rating. Guideline tables were then developed with treatment recommendations for key clinical situations
‡Also recommended concomitantly with an antipsychotic
§Recommended concomitantly with an antipsychotic; antipsychotic alone was another first-line option
|
