DEPAKOTE ER Once-Daily Dosing Recommendations¹

DEPAKOTE ER is Available in Tablet Form in 2 Strengths

Examples of Individualized Dosing

The starting dose in elderly patients should be reduced and dosage should be increased more slowly and with regular monitoring. The ultimate therapeutic dose should be achieved on the basis of both tolerability and clinical response.

Additional Dosing Information

• Depakote ER is an extended-release product intended for once-a-day oral administration
• Depakote ER tablets should be swallowed whole and should not be crushed or chewed
• No recommendation regarding the safety of valproate for use at doses above 60 mg/kg/day can be made
• May be taken without regard to meals
• The starting dose in elderly patients should be reduced and dosage should be increased more slowly and with regular monitoring. The ultimate therapeutic dose should be achieved on the basis of both tolerability and clinical response
• As with other valproate products, doses of Depakote ER should be individualized and dose adjustment may be necessary
• If a patient requires smaller dose adjustments than those available with Depakote ER, Depakote tablets should be used instead

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